Transcription Factors
Transcription factors regulate gene expression by controlling the
transcription of specific genes or gene families (Fig. 1.8). Typically, they contain
at least two domains: a DNA‐binding domain, such as a leucine
zipper or helix–loop–helix motif which binds to a specific DNA sequence, and an
activation domain, which contributes to assembly of the
transcription complex at a gene promoter. Mutation, deletion or translocation
of transcription factors underlie many cases of haematological neoplasms (see
Chapter 11).
